Super refractory status epilepticus pdf merge

Andrew cole, md of massachusetts general hospital and harvard medical school explains superrefractory status epilepticus. Super refractory status epilepticus is a medical emergency neces sitating aggressive treatment for early control seizures. The american epilepsy society guidelines published in. Many factors often combine to lower the patients seizure threshold. Management of refractory status epilepticus in adults. Table 2 medications used for refractory status epilepticus rse. Refractory and superrefractory status epilepticus indian pediatrics.

Pdf pharmacotherapy for status epilepticus researchgate. Srse is defined as status epilepticus that continues 24 h or more after the onset of anesthesia, including those cases in which the status epilepticus recurs on the reduction or withdrawal of anesthesia. Superrefractory status epilepticusstatus epilepticus that continues or recurs 24 hours or more after the onset of anesthetic therapyis a medical emergency. Common intravenous agents such as diazepam, lorazepam, midazolam, and phenytoin used to treat rse have frequent problems with toxicity or efficacy 35. Incidence and mortality of superrefractory status epilepticus in adults. This definition and the treatment guidelines have been subsequently revised. Pediatric status epilepticus treatment algorithm combining current guidelines. The treatment of superrefractory status epilepticus. Status epilepticus and beyond acute and critical care. Superrefractory status epilepticus explained youtube. Pdf refractory and superrefractory status epilepticus. Management of superrefractory status epilepticus with. Srse carries a high risk of morbidity and a high mortality rate ranging from 23 to 57% 2, 3.

Pharmacotherapy for pediatric convulsive status epilepticus. Pediatric intensive care treatment of uncontrolled status epilepticus. Dsmb chair of clinical trials of allopregnenolone for superrefractory status epilepticus. Many of the recommended doses or targeted therapeutic levels are higher than referenced in the literature and based upon expert opinions at nyph. This is a pdf file of an unedited manuscript that has. Pdf status epilepticus is the most severe form of epilepsy, with a high. Treatment of refractory and superrefractory status. Generalized convulsive status epilepticus emcrit project.

Transitioning treatment from status epilepticus to super refractory status epilepticus david roy, pharmd pgy1 pharmacy resident. Refractory status epilepticus rse is continued seizures after the failure of two or more aeds. With the use of the proposed protocol, combining midazolam and phenytoin. Superrefractory status epilepticus superrse refers to drugresistant status. More likely to be due to acute encephalitis 30516601.

Status epilepticus superrefractory fires epilepsy anesthesia pediatric. Pharmacotherapy for status epilepticus springerlink. Refractory status epilepticus is defined as status epilepticus. Refractory status epilepticus rse can be defined as status. Refractory to first and secondline antiepileptic agents. Guidelines for the evaluation and management of status epilepticus.